News & Topics


This year's  bachelor's thesis presentation was held .


B4 Nanase Takaba

「The emergence of novobiocin-resistant mutants in actinomycetes and their characteristics」



B4 Yuta Nakashima

「Analysis of mechanism for erythromycin resistance in actinomycetes-23S rRNA mutant」


This year's master's thesis presentation was held at the Graduation School of Science and Technology, Shinshu University.


The second year interim presentation of the Department of Biomedical Engineering,Graduate School of Medicine,Science and Technology was held.


D2 Kanata Hoshino 


 A class of genetic engineering experiments was carried out for two weeks and  successfully completed . All the members of our lab were active as Teaching Assistants.


D2 Kanata Hoshino of our lab will be hired as a Reserch Fellow DC2 of the Japan Society for the Promotion of Science in 2021.


The late has started with the newly assigned B3 students Eri Kaida and Ami Yoshimatsu.The two immediately finished their first task of updating the lab's nameboard. It was successfully taken over from the one created by the B4 graders .




A paper summarizing the research results of Keiichiro Mukai (The Graduate School of Medicine,Science and Technology)has been published in Current Microbiology.

It was revealed that the combination of the effect of rpoB mutation(mutation of RNA polymerase β subunit gene)and the concentration-dependent effect of the antibiotic lincomycin is effective in eliciting the potential secondary metabolic capacity of actinomycetes.


click here for details


Our lab has moved to a temporary lab to start renovation work. So we took out all the equipment and fixtures in the laboratory, redeployed them in the temporary laboratory, and finally resumed the experiment. It was a big event in the hot summer.


PhD. Nik, who worked hard on research activities together in our laboratory, returned to Thai safely after completing the one-year activity period.

She came to our Lab in the typhoon season a year ago, and this year she has been suffering from this covid-19 situation. It was a good experience for all the lab members to be able to share time with such a powerful teacher who are always positive in various situetions.  Thank you very much!



2020.7.1 (wed)

The Research Grant of Nagano Society for the Promotion of Science D1 Keiichiro Mukai was applying for has been adopted!

2020.6.1 (Mon)

Finally, this year's lab activities have started in earnest! It was the first time for a lab member, whose laboratory activities had been restricted due to the influence of COVID-19, to have such an unpleasant experience of experimenting. 


The 2020 Annal Meeting of The Japan Society for Bioscience, Biotechnology and Agrochemistry has been canceled due to the influence of COVID-19. Although we could not give a direct lecture, the following three subjects have been announced .


"Analysis of the fundamental mechanisms of single-colony diversification in Streptomyces vietnamensis NBRC 104153 " 

 Takeshi Hosaka, Ryo Morimoto, Takumi Kobayashi, Tomoko Maruyama, Ryoko Hamauzu


"Analysis of ribosome profiles for elucidating the mechanism by which lincomycin potentiates secondary metabolite production by Streptomyces strains"      

 Keiichiro Mukai, Momoko Kobayashi, Misaki Ishizuka, Yu Imai, Takeshi Hosaka


"Exploration and characterization of actinom ycetes that produce antibacterial compounds in the early growth stage"    

 Makiho Uchida, Teruya Kitagawa, Takeshi Hosaka



The graduation ceremony of the Faculty of Agriculture, Shinshu University, and the conferment ceremony for the graduate degree were held in the first year of the Reiwa. 

Masters's degree    Keiichiro Mukai and Ryo Morimoto

Bachelor's degree    Makiho Uchida, Takumi Kobayashi, Daiki Hayashi


2020.2.19      Associate professor Hosaka was invited to give a lecture at The 93rd Annual Meeting of Japanese Society for Bacteriology.

                       「Molecular physiological studies on actinomycetes for a fundamental understanding of antibiotics」

2020.2.14   The graduation paper thesis was held at Faculty of Agriculture , Shinshu University.


2020.2.6.  A master's thesis presentation was held at the Graduation School of Science and Technology, Shinshu University.

M2 Keiichiro Mukai

「The Fundamental mechanism Underlying the Lincomycin Induction of Secondary metabolism in Streptomyces coelicolor A3(2)

M2 Ryo Morimoto

「Analysis on the phenomenon for the phenotypic diversification of actinomycetes through isolation of their single colonies」


Our work has been published in Applied Microbiology and Biotechnology !

"A putative mechanism underlying secondary metabolite overproduction by Streptomyces strains with a 23S rRNA mutation conferring erythromycin resistance"   Kanata Hoshino(Ph.D. student)


Click here for details


It is a report of the happy activity of graduates!
Yu Imai(Ph.D.), who graduated from our laboratory, is currently working on further research at the Antimicrobial Discovery Center, Northeastern University in Boston.

His work has been published in Nature!
"A new antibiotic selectively kills Gram-negative pathogens" Yu Imai

Click here for details

2019.11.8 (Fri.)

We had an exchange meeting with  the Kodani lab of Shizuoka University  at night  before the symposium.

welcome to Shinshu-Ina!


 The 186 th annual meeting of  Japan Society for Bioscience, Biotechnology and Agrochemistry Chubu Branch will be held on  Saturday, November 9, 2019.


    click for website here


2019.9.23-24  We participated the 2019(34th) Annual Meeting of the Society for Actinomycetes  Japan @ Sapporo.

Oral Presentation:

"Analysis of mechanisms for the diversification of single colony morphology of actinomycete strains on agar plate"   M2 Ryo Morimoto


Poster Presentations:

" Analysis of the effects of ofloxacin-resistant mutations on secondary metabolism in actinomycetes"  D1 Kanata Hoshino

"Verification and characterization of antibacterial compound productivity by actinomycete strains isolated from subsurface soils"  M1 Teruya Kitagawa

"Activating properties and mechanisms for antibiotic induction of secondary metabolism in streptomycetes"  M1 Momoko Kobayashi





D1 Kanata Hoshino and M2 Ryo Morimoto participated in GIM 2019 in Pisa Italy (14th International Symposium on the Genetics of Industrial Microorganisms)! 
Oral presentation :D1 Kanata Hoshino
``"Specific 23S ribosomal RNA mutations conferring erythromycin resistance can enhance the frequency of spontaneous mutations in Streptomyces strains perturbing their secondary metabolism ''
Poster presentation  : M2 Ryo  Morimoto
``"Analysis on the phenomenon for the phenotypic diversification of actinomycetes through isolation of their single colonies ''